Home | Buy | Join Us | Why Collagen is Unique | Bio Research Overview | Testimonials | Contact us | More Info

SSL Certificates


Collageena and Health Professionals

Robert F. Diegelmann, PhD, From the Medical College of Virginia, Virginia Commonwealth University, Richmond, Virginia

Abstract and Introduction

The process of wound healing consists of an orderly sequence of events characterized by the specific infiltration of specialized cells into the wound site. The platelets and inflammatory cells are the first cells to arrive, and they provide key functions and signals needed for the influx of connective tissue cells and a new blood supply. These chemical signals are known as growth factors or cytokines. The fibroblast is the connective tissue cell responsible for collagen deposition needed to repair the tissue injury. Collagen is the most abundant protein in the animal kingdom, as it accounts for 30 percent of the total protein in the human body. In normal tissues, collagen provides strength, integrity, and structure. When tissues are disrupted following injury, collagen is needed to repair the defect and hopefully restore structure and thus function. If too much collagen is deposited in the wound site, normal anatomical structure is lost, function is compromised, and the problem of fibrosis results. Conversely, if insufficient amounts of collagen are deposited, the wound is weak and may dehisce. Therefore, to fully understand wound healing, it is essential to understand the basic biochemistry of collagen metabolism.

Collagen is found in all of our connective tissues, such as dermis, bones, tendons, and ligaments, and also provides for the structural integrity of all of our internal organs.[1,2] Therefore, because of its wide distribution throughout our bodies, it represents one of the most abundant naturally occurring proteins on earth.[3] In addition to its natural abundance, there are well over 1,000 commercial products on the market today that contain collagen and collagen enhancers. These products are represented by body and hand lotions, nail treatments, firming gels, wrinkle injections, eye pads, and even anti-cancer treatments to name but a few. In recent years, new high-tech wound dressing materials and skin substitutes have become available for the treatment of partial-thickness injuries as well as full-thickness and chronic dermal ulcers.

collagen, collagen supplement, collagen protein buy collagen, collagen supplement, collagen protein join us collagen why collagen in unique bio research collagen contacts info collagen print page
2009 © Collageena.com all rights reserved